The Correlation between Glycemic Control (HbA1c) and Nephropathy Diabetic among Type 2 Diabetes Mellitus Patients in Dr. Moewardi General Hospital Surakarta

Abstract

Background: Nephropathy diabetic is the one of the most serious long-term complications of diabetes mellitus which could lead to end stage renal disease. One of the factors that influences nephropathy diabetic is glycemic control that can be monitored trough HbA1c level. The uncontrolled HbA1c level can causes an increasing of end glycation product which could lead to glomerular injury in type 2 diabetic patients. This study aimed to determine whether there is correlation between glycemic control (HbA1c) and nephropathy diabetic among type 2 diabetic patients in Dr.Moewardi General Hospital Surakarta.

Methods: This study is an observational analytic with case control approach. Subjects in this study are type 2 diabetes mellitus patients with nephropathy diabetic and without nephropathy diabetic in Dr. Moewardi General Hospital Surakarta. Data of HbA1c level of subjects in this study were collected from medical records. Sampling was done by purposive sampling with 40 patients as the case and 40 patients as the control. The data were analyzed using chi square test and logistic regression.

Result: There is no significant correlation between control glycemic (HbA1c) with nephropathy diabetic with p-value = 0.528 (OR =1.378; CI 95% 0.509-3.727). Multivariate analysis shows that hypertension is the most influenced risk factor (OR = 4.255; CI 95% 1.538-11.437; p = 0.004) followed by duration of diabetes (OR = 3.432; CI 95% 1.254-9.397; p = 0.016, meanwhile dyslipidemia has no significant correlation with nephropathy diabetic (OR = 0.925; CI 95% 0.259-3.303; p = 0.904).

Conclution: There is no significant correlation between control glycemic (HbA1c) with nephropathy diabetic in diabetes mellitus type 2 in General Hospital Moewardi Surakarta.

Keywords: Glycemic Control (HbA1c), Nephropathy Diabetic, Diabetes Mellitus Type 2